Drugs and the Limbic System Drugs and the Limbic System The Limbic System The limbic system is a 'collective term denoting a heterogeneous array of brain structures at or near the edge of the medial wall of the cerebral hemisphere, in a particular the hippocampus, amygdala, and fornicate gyrus.' The limbic system is responsible for creating your feelings and motivation. Your feelings supply the contexts for your sensory and motor activities and can alter how one perceives the world and behaves in it. This portion of the brain physically connects the survival oriented brain stem with the cognitively oriented cortex. Parts of the Limbic System Drugs and the Limbic System All drugs that people abuse all change the way the limbic system works. Drugs disrupt the careful modulation of feelings and motivations that underlie normal behavior. When these feelings lose touch with reality, the person receives artificial relief, pleasure, contentment, and relaxation take over. ![]() The Brain Reward System The Brain Reward System is a specific limbic circuit that generates the feelings of pleasure. This system originates in a group of neurons that are located in the mid brain (called the ventral tegmental area, or VTA). These neurons then connect to a variety of places within the limbic system, but the important connection is to the nucleus accumbens in the basal ganglia. ![]() The basal ganglia are a large, complex set of structures within the limbic system that function in generating movements, some cognitive functions, emotional and motivational activities. When a drug activates the VTA neurons, these neurons release into the nucleus accumbens and the person feels pleasure. Key Components of the Brain Reward System,,,,. ![]() Fiziol Zh SSSR Im I M Sechenova. 1975 Jun;61(7):985-90. [The role of several limbic structures in neocortical activation following brain stem section at the level. The limbic system is a 'collective term denoting a heterogeneous array of brain structures at or near the edge of the medial wall of the cerebral hemisphere, in a particular the hippocampus. When a drug activates the VTA neurons, these neurons releasedopamine into the nucleus accumbens and the person feels pleasure. Simplification of Limbic Functions and Corresponding Key Structures. Main Components of the Limbic System. PET has shown decreased activation. These responses are heavily modulated by dopaminergic projections from the limbic system. In 1954, Olds and Milner found that rats with metal electrodes implanted into their nucleus accumbens, as well as their septal nuclei, repeatedly pressed a lever activating this region, and did so in preference to eating and drinking,. Individualized and Clinically Derived Stimuli Activate Limbic Structures in Depression: An fMRI Study Henrik Kessler1,2,9*, Svenja Taubner1,3, Anna Buchheim4, Thomas. ![]()
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